Vitamin E reduces myocardial infarct size in type 2 diabetes
نویسندگان
چکیده
منابع مشابه
Myocardial Infarct Size in Humans
Background. The influence of coronary collateral vessels on infarct size in humans remains controversial, partly because no previous study has examined the impact of collaterals present at the onset of acute myocardial infarction on infarct size. Methods and Results. The present study used the data base of the Thrombolysis in Myocardial Infarction (TIMI) Phase I trial to correlate the presence ...
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Acute myocardial infarction continues to be a major cause of morbidity and mortality. Timely reperfusion can substantially improve outcomes and the administration of cardioprotective substances during reperfusion is therefore highly attractive. Adenosine diphosphate (ADP) and uridine-5-triphoshate (UTP) are both released during myocardial ischemia, influencing hemodynamics. Both mediate the rel...
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Yumei Ye,* Jinqiao Qian,* Alexander C. Castillo, Shukuan Ling, Hongmei Ye, Jose R. Perez-Polo, Mandeep Bajaj, and Yochai Birnbaum Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas; Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China; Section of Endocrinology, Baylor College of Medicine, Ho...
متن کاملVitamin E reduces cardiovascular disease in individuals with diabetes mellitus and the haptoglobin 2-2 genotype.
AIMS Individuals with both diabetes mellitus (DM) and the Haptoglobin (Hp) 2-2 genotype are at increased risk of cardiovascular disease. As the antioxidant function of the Hp 2-2 protein is impaired, we sought to test the pharmacogenomic hypothesis that antioxidant vitamin E supplementation would provide cardiovascular protection to Hp 2-2 DM individuals. MATERIALS & METHODS We determined the...
متن کاملRelationship Between Myocardial Infarct Size
We compared myocardial infarct size produced by permanent occlusion of the middle left anterior descending (LAD) or circumflex (LCx) coronary artery in the anesthetized dog. The dogs were killed 3-10 days later, and the occluded coronary bed was visualized by postmortem arteriography. The outlines of the infarct and occluded bed were marked on tracings of weighed left ventricular (LV) rings and...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.5.a1153-c